Spaz is a new AIR based desktop Twitter client (they also have a Palm Pre version). In order to get pIqaD working in it you’ll need to add the following custom CSS hack:

div.status-text {
font-family:pIqaD, Palatino,Georgia, "Times New Roman", Times, serif;
}

body {
font-family:pIqaD, Tahoma, Arial, Helvetica, sans-serif;
}

Once you put this in the “Edit User CSS” popup in the preferences window pIqaD should show in the timeline and you can type pIqaD in the entry box.